Table 2.
Clinical and laboratory characteristics of patient.
| Parameter | Data |
|---|---|
| Demographic parameter | |
| Sex | f |
| Age y | 56 |
| Age of onset y | 54 |
| Psychopathology | |
| Orientation dysfunction | 1 |
| Attentional dysfunction | 1 |
| Memory disturbances | 1 |
| Formal thought disorder | 1 |
| Affective disturbance | 1 |
| Drive and psychomotor disturbance | 1 |
| CSF | |
| Cell count (<5 µL) | 0 |
| Albumin mg/L | 261 |
| NSE (<30 ng/mL) | 24.1 |
| S100 (<2.7 µg/L) | 1.6 |
| Tau protein (<450 pg/mL) | 128 |
| P tau protein 181 (<61 pg/mL) | 70 |
| Aß42 (>450 pg/mL) | 1539 |
| Aß40 | 19,275 |
| Ratio Aß42/40 × 10 (>0.5) | 0.8 |
| Blood–brain barrier disturbance | Not present |
| Intrathecal IgG synthesis | Not present |
| Serum | |
| NSE (<30 ng/mL) | 22.8 |
| S100 (<1.5 µg/L) | 0.06 |
| MRI | |
| Generalized atrophy | 0 * |
| Focal atrophy | 1 # |
| Hippocampal atrophy | 0 |
| Vascular pathology | 0 |
Abbreviations: Aß42 = amyloid-ß 42, Aß40 = amyloid-ß 40, CSF = cerebrospinal fluid, MRI = magnetic resonance imaging, p-tau protein 181 = phosphorylated tau protein 181, ratio Aß42/40 = ratio of amyloid-ß 42/ratio of amyloid-ß 40, y = years. The values are depicted as mean ± standard deviation. For laboratory data normal ranges are shown in brackets. Reference values: refers to reference values from the Neurochemistry Laboratory, Neurology Department, University Medical Center Göttingen. * 0 = item not present, # 1 = item present.