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. 2023 Jan 11;13(1):125. doi: 10.3390/brainsci13010125

Table 3.

Criteria for the autoimmune genesis of the symptomatology.

I Definitive limbic autoimmune encephalitis according to Graus et al. [11]
Criterion Completion of Criterion
A. Subacute presentation of cognitive dysfunction with working memory deficits together with psychiatric symptoms (depressive symptoms) Yes
B. T2/FLAIR MRI signal changes in temporal lobe No
C. CSF pleocytosis or temporal EEG abnormalities No
D. Detection of neural autoantibodies in serum and CSF Yes
E. Exclusion of other reasons Yes
Sum 3 of 4 required criteria = no definitive limbic autoimmune encephalitis
II Definitive autoimmune based psychiatric syndrome according to Hansen et al. [10]
Criterion Completion of Criterion
A. Minor cognitive impairment Yes
B. Severe cognitive dysfunction Yes
C. Two items: elevated ptau181 and presence of serum Homer-3 autoantibodies Yes
D. Presence of CSF IgG Homer-3 autoantibodies Yes
Sum 4 of 4 required criteria = definitive autoimmune based psychiatric syndrome