I Definitive limbic autoimmune encephalitis according to Graus et al. [11] |
Criterion
|
Completion of Criterion
|
A. Subacute presentation of cognitive dysfunction with working memory deficits together with psychiatric symptoms (depressive symptoms) |
Yes |
B. T2/FLAIR MRI signal changes in temporal lobe |
No |
C. CSF pleocytosis or temporal EEG abnormalities |
No |
D. Detection of neural autoantibodies in serum and CSF |
Yes |
E. Exclusion of other reasons |
Yes |
Sum |
3 of 4 required criteria = no definitive limbic autoimmune encephalitis |
II Definitive autoimmune based psychiatric syndrome according to Hansen et al. [10] |
Criterion
|
Completion of Criterion
|
A. Minor cognitive impairment |
Yes |
B. Severe cognitive dysfunction |
Yes |
C. Two items: elevated ptau181 and presence of serum Homer-3 autoantibodies |
Yes |
D. Presence of CSF IgG Homer-3 autoantibodies |
Yes |
Sum |
4 of 4 required criteria = definitive autoimmune based psychiatric syndrome |