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Combined mOSCC p63-based signature. (A) Heat map of the combined 22-gene signature in the B7E11 cells with p63 knockdown, B7E3 cells with induced p63 expression, and the Tang et al. [11] 4NQO mOSCC dataset. Genes in boldface are direct targets of p63, according to our high-confidence p63 target list. (B) Western blot analysis of the levels of proteins encoded by DEGs identified in our combined p63-based signature in B7E3 p63 overexpressing cells. GAPDH was used as a loading control.
