Figure 7.

scRNA-seq analysis of 4NQO-induced mouse ESCC shows enrichment of our p63-based OSCC gene signature. (A) UMAP clustering of different cell types in mouse ESCC tumors. (B) UMAPs shows a zoomed-in cancer cell cluster highlighted from overall UMAP clustering. UMAP distribution of p63 expression across tumor cell clusters highlights p63^high and p63^low populations. DEG analysis of p63^high versus p63^low cells shows enrichment of several DEGs previously identified in the p63-based gene expression signature. UMAP projections display the expression of these factors across the tumor cell population. Enriched hallmark terms in DEGs enriched in p63^low (C) and p63^high (D) cells.