Table 2. Association of the PRS With AD Dementia, aMCI, and Aβ Deposition.
| Measure | OR (95% CI) | P value |
|---|---|---|
| AD dementia diagnosisa | ||
| Data set 1 | 1.95 (1.40-2.72) | <.001 |
| Data set 2 | 1.85 (1.05-3.32) | .04 |
| aMCI diagnosisb | 1.74 (1.16-2.64) | .008 |
| Aβ PET depositionc | 1.81 (1.32-2.48) | <.001 |
Abbreviations: Aβ, amyloid β; AD, Alzheimer disease; aMCI, amnestic mild cognitive impairment; CU, cognitively unimpaired; OR, odds ratio; PC, principal component; PET, positron emission tomography; PRS, polygenic risk score.
a
Diagnosis (CU = 0, AD dementia = 1) = sex + age + education year + PC1-4 + APOE ε4 carrier (0 or 1) + PRS.
b
Diagnosis (CU = 0, aMCI = 1) = sex + age + education year + PC1-4 + APOE ε4 carrier (0 or 1) + PRS.
c
Aβ deposition (negative = 0, positive = 1) = sex + age + education year + PC1-4 + APOE ε4 carrier (0 or 1) + PRS.