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. 2023 Jan 9;12(2):262. doi: 10.3390/cells12020262

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Liver damage after SARS-CoV-2 infection. Severe chronic portal inflammation is observed in livers of patients with acute COVID-19 (Panels (A,B), Hematoxylin and Eosin, original magnification 200× and 400×, respectively). At higher magnification the fragmented nuclei of apoptotic hepatocytes are present (Panel (C), arrow), as well as Binucleation of hepatocytes (Panel (D), arrow). In severe cases, extensive areas of necrosis were observed (Panel (E)) Panels (C–E), Hematoxylin & Eosin, original magnification 400×.