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(a) Inosine monophosphate (IMP) levels were significantly higher in CB-839 treated T98G and LN229 cells; 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) levels significantly increased for treated T98G and U87MG cells. (b) Uridine monophosphate (UMP) was significantly decreased by specific GLS inhibitor CB-839 in T98G and LN229. The samples were run in triplicate. For more details, see Section 2. ns—non-significant. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.
