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The methylation ratio was significantly increased by treatment with the specific GLS inhibitor CB-839 in the assayed GBM cell lines. Fold change is represented for 3-methyladenine (a), N,N,N-trimethyl-lysine (b), and 5-methylcytosine (c): the last increasing only in T98G. The samples were run in triplicate. For more details, see Section 2. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.
