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. 2023 Jan 14;12(2):324. doi: 10.3390/cells12020324

Figure 3.

Figure 3

Schematic representation of N- and O-glycosylation of integrins by glycosyltransferases and associated functions. The N-glycan structure is involved in heterodimerization, ligand binding, cell trafficking, and the degradation rate of integrins. N-glycans regulate cell adhesion and migration and, consequently, cancer progression. Fut 8, α1,6-fucosyltransferase; GalT, hydroxyproline-O-galactosyltransferase; GnT-III, β1,4-N-acetylglucosaminyltransferase III; GnT-V, β1,6 N-acetylglucosaminyltransferase V; ST6Gal-I, ST6 β-galactoside α2,6-sialyltransferase I. Reprinted with permission from reference [135].