Table 1.
Demographic characteristics and clinical-pathologic data. PDS: primary debulking surgery; IDS: interval debulking surgery; FIGO: International Federation of Gynecology and Obstetrics; HGSOC: high grade serous ovarian cancer; EBL: estimated blood loss.
| Variables | Total | PDS | IDS | p * |
|---|---|---|---|---|
| Age years, median (range) | 59.6 (28–90) | 59 (35–90) | 61 (28–80) | 0.22 |
| Body Mass Index, median (range) | 26.2 (17–51) | 26.2 (17–51) | 26.3 (18–44) | 0.63 |
| Pre-operative CA 125 (UI/mL) | ||||
| Negative, n (%) | 7 (7.1%) | 7 (10.4%) | 0 (0%) | 0.67 |
| <500 UI/mL, n (%) | 35 (35.7%) | 23 (34.3%) | 12 (38.7%) | |
| ≥500 UI/mL, n (%) | 56 (57.1%) | 37 (55.2%) | 19 (61.3%) | |
| FIGO stage | ||||
| IIIA, n (%) | 9 (9%) | 9 (13%) | 0 (0%) | 0.001 |
| IIIB, n (%) | 5 (5%) | 5 (7.2%) | 0 (0%) | |
| IIIC, n (%) | 61 (61%) | 47 (68.2%) | 17 (54.8%) | |
| IVA, n (%) | 5 (5%) | 2 (2.9%) | 3 (9.7%) | |
| IVB, n (%) | 17 (17%) | 6 (8.7%) | 11 (35.5%) | |
| Histology | ||||
| HGSOC, n (%) | 83 (83%) | 54 (78.3%) | 29 (93.5%) | 0.06 |
| Non-HGSOC, n (%) | 17 (17%) | 15 (21.7%) | 2 (6.5%) | |
| Surgical complexity score | ||||
| 1, n (%) | 11 (11%) | 6 (8.7%) | 5 (16.1%) | 0.28 |
| 2, n (%) | 21 (21%) | 14 (20.3%) | 7 (22.6%) | |
| 3, n (%) | 68 (68%) | 49 (71%) | 19 (61.3%) | |
| Residual Disease | ||||
| R0, n (%) | 74 (74%) | 50 (72.5%) | 24 (77.4%) | 0.51 |
| R1 (0.1–1 cm), n (%) | 22 (22%) | 15 (21.7%) | 7 (22.6%) | |
| R2 (>1 cm), n (%) | 4 (4%) | 4 (5.8%) | 0 (0%) | |
| Upper abdomen procedures (UAP) | ||||
| Yes | 84 (84%) | 58 (84.1%) | 26 (83.9%) | 0.98 |
| No | 16 (16%) | 11 (15.9%) | 5 (16.1%) | |
| Operative time (min), median (range) | 422.5 (90–870) | 421.5 (90–870) | 424.7 (170–700) | 0.74 |
| EBL (mL), median (range) | 428.9 (50–2000) | 460.9 (50–2000) | 362.9 (50–900) | 0.36 |
| Number of intra-operative transfusion (n), median (range) | 0.4 (0–1) | 0.4 (0–1) | 0.5 (0–1) | 0.7 |
| Length of hospital stay (days **), median (range) | 17.4 (0–68) | 18 (0–68) | 16.1 (3–60) | 0.54 |
* Categorical data were compared with the χ2 test or Fisher’s exact test, as appropriate. The Mann–Whitney test was used to compare continuous variables. ** Calculated from the hospital admission to discharge after final surgery.