The impact of Immunoscore on the outcome of patients with early-stage (Stage I/II) colon cancer. Kaplan-Meier curves of Immunoscore (I) are shown for TTR (A,C,E,G) and DFS (B,D,F,H) for patients from cohort 1 (A,B), cohort 2 (C,D), all patients from cohort 1+2 (E–H). (A–F) Immunoscore two categories: I Lo (0–25%, black), I Int + Hi (>25–100%, red). (G,H) Immunoscore three categories: I Lo (0–25%, black), I Int (>25–70%, green) and I Hi (>70–100%, red). Relative importance of each risk parameter to survival risk for TTR (I) and DFS (J) using the χ2 proportion test for clinical parameters and Immunoscore corresponding to panels G and H. Significant logrank p-values are marked as *** p < 0.001, ** 0.001 < p ≤ 0.01, * 0.01 < p ≤ 0.05.