Figure 4.

Protein–protein interaction networks for 43 lymphangiogenesis guidance molecules by STRING (Search Tool for the Retrieval of Interacting Genes/Proteins) analysis. By direct/indirect interactions with other guidance molecules Notch1, Nrp2, Fgf2, Vegfa, Kdr, Flt1, Ephb4, Flt4, and FOXC2 may act as master regulators mediating corneal lymphangiogenesis, providing potential avenues for the development of anti-lymphangiogenic therapies for corneal inflammatory pathologies including dry eye disease and cornea graft rejection.