Table 1.

Pre-treatment biomarkers for irAEs.

irAE	Biomarker	Biomarker Assessment	No of Papers
Thyroid	TSH	Higher levels	5 [28,29,30,31,32]
	TgAbs and/or TPOAbs	Presence	10 [28,29,31,32,33,34,35,36,37,38]
	IL-1β	Higher levels	1 [40]
	IL-2	Higher levels	1 [40]
	GM-CSF	Increase	1 [40]
Pituitary
Hypopituitarism	Anti-GNAL Abs	Presence	1 [45]
	HLA-DR15	Presence	2 [42,43]
	HLA-B52	Presence	1 [42]
	HLA-Cw12	Presence	2 [42,43]
Isolated ACTH deficiency	Anti-pituitary Abs	Presence	1 [43]
	HLA-DR15	Presence	1 [43]
	HLA-Cw12	Presence	1 [43]
	HLA-DQ7	Presence	1 [43]
	HLA-DPw9	Presence	1 [43]
	HLA-DRB5*01:02	Presence	1 [44]
	HLA-DPB1*09:01	Presence	1 [44]
	HLA-DQA1*01:03	Presence	1 [44]
	HLA-DQB1*06:01	Presence	1 [44]
Diabetes Mellitus	HLA-DR4	Presence	1 [57]
	HLA-DPA1*02:02	Presence	1 [56]
	DPB1*05:01	Presence	1 [56]
	HLA-DRB1*04:05	Presence	5 [44,58,59,60,61]
	HLA-DPA1*02: 02-DPB1*05:01	Presence	1 [44]
Endocrine	Absolute Eosinophilic count	Higher levels	1 [51]