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. 2023 Jan 12;15(2):478. doi: 10.3390/cancers15020478

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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IR-sensitive HNSCC tumors show more unresolved DNA damage. (A) 53BP1 foci count per nuclear volume in the IR-resistant and -sensitive samples. Violin plots represent all scored nuclei, the horizontal line depicts the median, and error bars show the interquartile range. (B) 53BP1 foci size in the IR-resistant and -sensitive samples. Violin plots represent all scored foci, the horizontal line depicts the median, and error bars show the interquartile range. Differences were tested with the Kruskal–Wallis test. ** p < 0.001.