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(a) The structure and enzyme inhibition IC50 of the CAMKK2 probe molecule. (b) The selectivity of compound 5 (SGC-CAMKK2-1) depicted using a TREEspot diagram obtained from profiling SGC-CAMKK2-1 at 1 µM in the KinomeSCAN® assay panel. PoC = percentage of control. A PoC of 100 indicates no binding and a PoC = 0 is reflective of complete binding. Thus, kinases with PoC values closer to zero are the assay hits and are the kinases to which our compound binds.
