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Western blot analysis of endogenous CAMKK2 inhibition using p-AMPK(Thr172) levels as a marker of CAMKK2 cellular activity. Western blot images (top) and densitometry analyses (bottom) of C4-2 cells treated with increasing doses of (a) STO-609, (b) probe SGC-CAMKK2-1 (5), and (c) negative control SGC-CAMKK2-1N (7). IC50 for STO-609 = 10.7 μM, SGC-CAMKK2-1 probe = 1.6 μM, and negative control SGC-CAMKK2-1N ≥10 μM. Results represent values from three individual experiments.
