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. 2023 Jan 11;12(2):287. doi: 10.3390/cells12020287

Scheme 1.

Scheme 1

Synthetic route to compounds 5 and 6. Reagents and conditions (a) 8, Pd(dppf)Cl2 (0.05 eq.), Cs2CO3 (2 eq.), 1,4-dioxane/water (4:1), 120 °C microwave, 30 min; (b) ArB(OH)2 (1 eq.), Pd(dppf)Cl2 (0.05 eq.), Cs2CO3 (2 eq.), 1,4-dioxane/water (4:1), 120 °C microwave, 30 min; (c) 1 N NaOH, MeOH, 75 °C then aq. HCl, 1 h.