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. 2023 Jan 13;15(2):502. doi: 10.3390/cancers15020502

Figure 4.

Figure 4

Summary of NF-κB mediated signal transduction regulating adipogenesis and lipolysis. (A) Pro-inflammatory signals activate NF-κB signaling to mediate adipocyte dedifferentiation and lipolysis. Secondary messengers are secreted to initiate an inflammatory signal cascade in adipocytes. (B) Autocrine and paracrine signals from NF-κB-activated adipocytes also regulate adipogenesis and lipolysis. Abbreviations: WNT3, Wnt family member 3; WNT3R, Wnt family member 3 receptor; WNT10A, Wnt family member 10A; CCL2, C–C motif chemokine ligand 2; CCR2, C-C chemokine receptor type 2; MAPK, Mitogen-activated protein kinases; PI3K, Phosphatidylinositol 3,4,5-trisphosphate kinase; AKT, protein kinase B; IL6, Interleukin 6; IL11, Interleukin 11; IL6R, Interleukin 6 receptor; IL11R, Interleukin 11 receptor; JAK, Janus family tyrosine kinase; IL1B, Interleukin 1B; MYD88, Myeloid differentiation primary response 88; TRAF6, Tumor necrosis factor receptor-associated factor 6; NF-κB, Nuclear factor kappa-light-chain-enhancer of activated B cells; IL15, Interleukin 15; MCP-1, monocyte chemoattractant protein-1; COX-2, cyclooxygenase-2; 5-LOX, 5-lipoxygenase; 12-LOX, 12-lipoxygenase; CCND1, Cyclin D1; VEGFA, vascular endothelial growth factor A; CASP, caspase; TP53, tumor protein p53; BCL2, B-cell lymphoma 2; JAK, Janus family tyrosine kinase; STAT3, Signal transducer and transcription 3; AC, Adenylyl cyclase; PKA, Protein kinase A; PPARΥ, Peroxisome proliferator-activated γ; CEBP, CCAAT/enhancer binding protein; ATGL, adipose triglyceride lipase; HSL, hormone-sensitive lipase; PLIN, Perilipin1.