Table 5.
Performance Values | SRS (%) | CI including SRS (%) | 68Ga-DOTANOC PET/CT (%) | p PET/CT vs. CI | p PET/CT vs. SRS |
---|---|---|---|---|---|
Liver | |||||
Se | 77.1% (37/48) [63.5–86.7] | 95.8% (46/48) [86.0–99.3] | 97.9% (47/48) [89.1–1.0] | NS | p = 0.004 |
Sp | 100% (57/57) [93.7–100] | 89.5% (51/57) [78.9–95.1] | 100% (57/57) [93.7–100] | p = 0.004 | NS |
PPV | 100% (37/37) [90.6–100] | 88.5% (46/52) [77.0–95.0] | 100% (47/47) [92.4–100] | ||
NPV | 83.8% (57/68) [73.3–90.7] | 96.2% (51/53) [87.3–99.3] | 98.3% (57/58) [90.9–99.9] | ||
Accuracy | 89.5% (94/105) | 92.4% (97/105) | 99.1% (104/105) | ||
Peritoneal carcinomatosis | |||||
Se | 15.0% (3/20) [5.2–36.0] | 30.0% (6/20) [14.6–51.9] | 95.0% (19/20) [76.4–99.7] | p < 0.001 | p < 0.001 |
Sp | 97.7% (83/85) [91.8–99.6] | 97.7% (83/85) [91.8–99.9] | 98.8% (84/85) [93.6–99.9] | NS | NS |
PPV | 60% (3/5) [23.1–92.9] | 75,0% (6/8) [40.9–95.6] | 95.0% (19/20) [76.4–99.7] | ||
NPV | 83.0% (83/100) [74.5–89.1] | 85.6% (83/97) [77.2–91.2] | 98.9% (84/85) [93.6–99.9] | ||
Accuracy | 81.0% (86/105) | 84.8% (89/105) | 98.1% (103/105) | ||
Bone | |||||
Se | 33.3% (3/9) [12.1–64.6] | 33.3% (3/9) [12.1–64.6] | 100% (9/9) [70.1–100] | p = 0. 041 | p = 0.041 |
Sp | 100% (96/96) [96.2–100] | 99.0% (95/96) [94.3–100] | 100% (96/96) [96.2–100] | NS | NS |
PPV | 100% (3/3) [43.9–100] | 75.0% (3/4) [30.1–98.7] | 100% (9/9) [70.1–100] | ||
NPV | 94.1% (96/102) [87.8–97.3] | 94.1% (95/101) [87.6–97.3] | 100% (96/96) [96.2–100] | ||
Accuracy | 94.3 (99/105) | 93.3 (98/105) | 100% (105/105) | ||
Other sites | |||||
Se | 42.9% (3/7) [15.8–75.0] | 71.4% (5/7) [35.9–94.9] | 100% (7/7) [64.6–100] | NS | NS |
Sp | 98.0 % (96/98) [92.9–99.6] | 94.9% (93/98) [88.6–97.8] | 100% (98/98) [96.2–100] | NS | NS |
PPV | 60.0 % (3/5) [23.1–93.0] | 50.0% (5/10) [23.7–76.3] | 100% (7/7) [64.6–100] | ||
NPV | 96.0 % (96/100) [90.2–98.4] | 97.9% (93/95) [92.7–99.6] | 100% (98/98) [96.2–100] | ||
Accuracy | 94.3 % (101/105) | 93.3% (100/105) | 100% (105/105) |
CI: conventional imaging; NS: not significant; NPV: negative predictive value; PET/CT: positron emission tomography combined with computed tomography; PPV: positive predictive value; Se: sensitivity; Sp: specificity; SRS: somatostatin receptor scintigraphy.