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. 2023 Jan 14;15(2):513. doi: 10.3390/cancers15020513

Table 5.

Sensitivities, specificities, positive predictive values, negative predictive values, and accuracies of Optimized Octreoscan® scintigraphy, Conventional Imaging and 68Ga-DOTANOC PET/CT at metastatic sites’ levels.

Performance Values SRS (%) CI including SRS (%) 68Ga-DOTANOC PET/CT (%) p PET/CT vs. CI p PET/CT vs. SRS
Liver
Se 77.1% (37/48) [63.5–86.7] 95.8% (46/48) [86.0–99.3] 97.9% (47/48) [89.1–1.0] NS p = 0.004
Sp 100% (57/57) [93.7–100] 89.5% (51/57) [78.9–95.1] 100% (57/57) [93.7–100] p = 0.004 NS
PPV 100% (37/37) [90.6–100] 88.5% (46/52) [77.0–95.0] 100% (47/47) [92.4–100]
NPV 83.8% (57/68) [73.3–90.7] 96.2% (51/53) [87.3–99.3] 98.3% (57/58) [90.9–99.9]
Accuracy 89.5% (94/105) 92.4% (97/105) 99.1% (104/105)
Peritoneal carcinomatosis
Se 15.0% (3/20) [5.2–36.0] 30.0% (6/20) [14.6–51.9] 95.0% (19/20) [76.4–99.7] p < 0.001 p < 0.001
Sp 97.7% (83/85) [91.8–99.6] 97.7% (83/85) [91.8–99.9] 98.8% (84/85) [93.6–99.9] NS NS
PPV 60% (3/5) [23.1–92.9] 75,0% (6/8) [40.9–95.6] 95.0% (19/20) [76.4–99.7]
NPV 83.0% (83/100) [74.5–89.1] 85.6% (83/97) [77.2–91.2] 98.9% (84/85) [93.6–99.9]
Accuracy 81.0% (86/105) 84.8% (89/105) 98.1% (103/105)
Bone
Se 33.3% (3/9) [12.1–64.6] 33.3% (3/9) [12.1–64.6] 100% (9/9) [70.1–100] p = 0. 041 p = 0.041
Sp 100% (96/96) [96.2–100] 99.0% (95/96) [94.3–100] 100% (96/96) [96.2–100] NS NS
PPV 100% (3/3) [43.9–100] 75.0% (3/4) [30.1–98.7] 100% (9/9) [70.1–100]
NPV 94.1% (96/102) [87.8–97.3] 94.1% (95/101) [87.6–97.3] 100% (96/96) [96.2–100]
Accuracy 94.3 (99/105) 93.3 (98/105) 100% (105/105)
Other sites
Se 42.9% (3/7) [15.8–75.0] 71.4% (5/7) [35.9–94.9] 100% (7/7) [64.6–100] NS NS
Sp 98.0 % (96/98) [92.9–99.6] 94.9% (93/98) [88.6–97.8] 100% (98/98) [96.2–100] NS NS
PPV 60.0 % (3/5) [23.1–93.0] 50.0% (5/10) [23.7–76.3] 100% (7/7) [64.6–100]
NPV 96.0 % (96/100) [90.2–98.4] 97.9% (93/95) [92.7–99.6] 100% (98/98) [96.2–100]
Accuracy 94.3 % (101/105) 93.3% (100/105) 100% (105/105)

CI: conventional imaging; NS: not significant; NPV: negative predictive value; PET/CT: positron emission tomography combined with computed tomography; PPV: positive predictive value; Se: sensitivity; Sp: specificity; SRS: somatostatin receptor scintigraphy.