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. 2023 Jan 16;15(2):546. doi: 10.3390/cancers15020546

Figure 4.

Figure 4

Brequinar (BQR) synergizes with cisplatin (DDP) to inhibit the growth of cervical cancer cells in vivo. (A) Images of nude mice with subcutaneous tumor injected by HeLa cells. Groups of mice were treated with BQR (15 mg/kg) and/or DDP (7 mg/kg) as indicated (n = 8 per group). (B) Growth curves of HeLa tumors of each group. * p < 0.05, ** p < 0.01, *** p < 0.001 compared to the control group. (C) Images of resected tumors from each group, and tumor mass of HeLa tumors of each group. ** p < 0.01, *** p < 0.001 compared to the control group. (D) Body weight of nude mice in each group. (E) Representative images of IHC staining for Ki-67 and 4-HNE, and representative images of TUNEL staining from sections of xenografted tumors. Scale bar = 250 μm.