Video 4.
Microglia screen myelin along the spinal cord and phagocytose myelin debris. Confocal time-lapse imaging of zebrafish spinal cords shows microglial processes extending and retracting along myelin sheaths (in 3-min intervals), few microglia migrating along the spinal cord to scan myelin in non-random patterns (in 20-min intervals), microglial uptake of a myelin fragment (indicated by arrow, acquired in 3-min intervals), and trafficking of myelin fragments within microglia (in 3-min intervals). Pseudo-coloring shows microglia in green and myelin in magenta. Frame rate is 2.5/s. Related to Figs. 3 and S2.