Table 4. Performance-Based Metrics of 1 Year Posttransplant Global Functional Health by Pretransplant Frailty Status in the Subgroup of 210 FrAILT Study Participants.
| Metrics at 1 y posttransplanta | Median (IQR) | P value | ||
|---|---|---|---|---|
| All (n = 210 [100%]) | Pretransplant frailty status | |||
| Frailty (≥4.5) (n = 41 [20%]) | No frailty (<4.5) (n = 169 [80%]) | |||
| LFI score (1 y post-transplant) | 3.4 (2.9 to 4.0) | 4.0 (3.5 to 4.6) | 3.4 (2.8 to 3.8) | <.001 |
| LFI components | ||||
| Grip strength z score | 0.1 (−0.5 to 0.8) | −0.1 (−0.9 to 0.5) | 0.2 (−0.4 to 0.8) | .01 |
| Chair stands per second | 0.5 (0.4 to 0.7) | 0.4 (0.3 to 0.5) | 0.5 (0.4 to 0.7) | <.001 |
| % With balance <30 s | 10 | 19 | 8 | .05 |
| Frailty categories, % | ||||
| Robust | 36 | 5 | 43 | <.001 |
| Prefrailty | 51 | 68 | 47 | |
| Frailty | 13 | 27 | 10 | |
| Fried frailty phenotype | 1 (0 to 2) | 1 (1 to 2) | 1 (0 to 1) | .01 |
| % With Fried frailty phenotype ≥3 | 11 | 15 | 10 | .39 |
| Fried frailty phenotype components, % | ||||
| Weakness | 31 | 49 | 27 | .01 |
| Slowness | 12 | 15 | 12 | .60 |
| Exhausted | 17 | 20 | 16 | .64 |
| Low physical activity | 28 | 34 | 27 | .34 |
| Unintentional weight loss | 15 | 24 | 12 | .08 |
| Average walk speed, m/s | 4.2 (3.4 to 5.1) | 4.4 (3.6 to 5.9) | 4.1 (3.3 to 5.0) | .08 |
| SPPB | 12 (10 to 12) | 10 (9 to 12) | 12 (11 to 12) | <.001 |
| % With SPPB≤9 | 24 | 42 | 20 | .01 |
| SPPB components | ||||
| Walk score | 4 (4 to 4) | 4 (3 to 4) | 4 (4 to 4) | .04 |
| Balance score | 4 (4 to 4) | 4 (4 to 4) | 4 (4 to 4) | .02 |
| Chair stands score | 4 (3 to 4) | 3 (1 to 4) | 4 (3 to 4) | <.001 |
Abbreviations: FrAILT, Functional Assessment in Liver Transplantation; LFI, Liver Frailty Index; SPPB, Short Physical Performance Battery.
a
Mann-Whitney or Fisher exact tests.