Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
The miRNA decay by target-directed miRNA degradation (TDMD). (a) Distinct outcomes of target recognition: target repression vs. TDMD. (b) A long ncRNA Cyrano mediates TDMD of miR-7. ZSWIM8, an E3 ubiquitin ligase, binds to AGO2 and induces polyubiquitination and degradation of AGO2. By comparison, Cdr1as, a circular RNA with more than 70 binding sites for miR-7, interacts with miR-7 and prevents miR-7 from downregulation.
