1. Medication: Use of opioid analgesia

2. ECOG-PS at baseline: Physician-assessed

3. ECOG-PS at baseline: Patient-assessed

4. ECOG-PS Day 8: Physician-assessed

5. ECOG-PS Day 8: Patient-assessed

6. MSAS-SF: Number of symptoms

7. MSAS-SF: Physical symptom subscale score (MSASPHYS)

8. MSAS-SF: Psychological symptom subscale score (MSASPSYCH)

9. MSAS-SF: Total symptom distress score (TMSAS)

10. MSAS-SF: Global Distress Index (GDI)

11. PSQI: Usual Bedtime (BT)

12. PSQI: Time to fall asleep (SOL)

13. PSQI: Usual getting up time (GUT)

14. PSQI: Hours of sleep per night (TST)

15. PSQI: Sleep disturbance—Cannot get to sleep within 30 min

16. PSQI: Sleep disturbance—Wake up in the middle of the night or early morning

17. PSQI: Sleep disturbance—Have to get up to use bathroom

18. PSQI Sleep disturbance—Cannot breathe comfortably

19. PSQI Sleep disturbance—Cough or snore loudly

20. PSQI Sleep disturbance—Feel too cold

21. PSQI Sleep disturbance—Feel too hot

22. PSQI: Sleep disturbance—Had bad dreams

23. PSQI: Sleep disturbance—Have pain

24. PSQI: Subjective sleep quality

25. PSQI: Use of medication for sleep

26. PSQI: Daytime dysfunction: Trouble staying awake

27. PSQI: Keep up enough enthusiasm to get things done

28. PSQI: Presence of bed partner or roommate

29. PiPS-B algorithm: Abbreviated Mental Test Score (out of 10)

30. PiPS-B algorithm: Patient’s pulse rate

31. PiPS-B algorithm: Global Health Status Score (1 = extremely poor health; 7 = normal health)

32. PiPS-B algorithm: Clinician’s estimate of survival (Days/Weeks/Months+)

33. Modified Glasgow Prognostic Score (mGPS)

34. Bloods: Haemoglobin (g/L) (130–180)

35. Bloods: White Blood Count (109/L) (4–11)

36. Bloods: Neutrophils (109/L) (2.0–7.5)

37. Bloods: Lymphocytes (109/L) (1.0–4.0)

38. Bloods: Platelets (109/L) (150–450)

39. Bloods: Sodium (mmol/L) (133–146)

40. Bloods: Potassium (mmol/L) (3.5–5.3)

41. Bloods: Urea (mmol/L) (2.5–7.8)

42. Bloods: Creatinine (µmol/L) (64–104)

43. Bloods: ALP (IU/L) (30–130)

44. Bloods: ALT (IU/L) (<50)

45. Bloods: Albumin (g/L) (35–50)

46. Bloods: C-reactive protein (CRP) (mg/L) (<10)

47. Wrist actigraphy: Rest-activity parameter—Dichotomy Index (I < O) at least 72 h

48. Wrist actigraphy: Rest-activity parameter—r24 (autocorrelation coefficient) at least 72 h

49. Wrist actigraphy: Activity parameters—Mean activity during wakefulness at least 72 h

50. Wrist actigraphy: Activity parameters—Mean daily activity (MDA) at least 72 h

51. Wrist actigraphy: Sleep parameter—Bedtime (BT)

52. Wrist actigraphy: Sleep parameter—Get up time (GUT)

53. Wrist actigraphy: Sleep parameter—Time in bed (TIB)

54. Wrist actigraphy: Sleep parameter—Total sleep time (TST)

55. Wrist actigraphy: Sleep parameter—Sleep onset latency (SOL)

56. Wrist actigraphy: Sleep parameter—Sleep Efficiency (%)

57. Wrist actigraphy: Sleep parameter—Wake after sleep onset (WASO)

58. Wrist actigraphy: Sleep parameter—Number of awake episodes (NA)

59. Consensus Sleep Diary: Time in bed (BT)

60. Consensus Sleep Diary: Time of final awakening

61. Consensus Sleep Diary: Time out of bed (GUT)

62. Consensus Sleep Diary: Time tried to go to sleep

63. Consensus Sleep Diary: Time to fall asleep (SOL)

64. Consensus Sleep Diary: Quality of Sleep

65. Consensus Sleep Diary: Total amount of time awakenings lasted (WASO)

66. Consensus Sleep Diary: Number of times awakened in the night (NA)