Table 2. Patient Psychiatric Medical History and Administered Drugs at Readmission for Postpartum Depression or Suicide Attempt.
| Total (N = 804 617), No. (%) | Admission for suicide attempt at delivery (n = 1202) | Readmission for depression within 1 y post partum (n = 468) | Readmission for suicide attempt within 1 y post partum (n = 111) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| No. (%) | OR (95% CI) | P value | No. (%) | OR (95% CI) | P value | No. (%) | OR (95% CI) | P value | ||
| Psychiatric medical history before admission for delivery | ||||||||||
| Depression | ||||||||||
| Total | 2202 (0.27) | 24 (2.00) | 7.50 (4.99-11.25) | <.001 | 72 (15.39) | 68.46 (53.07-88.32) | <.001 | 14 (12.61) | 52.92 (30.17-92.83) | <.001 |
| Uncomplicateda | 1238 (0.15) | 10 (0.83) | 5.48 (2.93-10.24) | <.001 | 22 (4.70) | 32.57 (21.15-50.16) | <.001 | 3 (2.70) | 18.07 (5.73-56.98) | <.001 |
| Schizophrenia | ||||||||||
| Total | 1262 (0.16) | 14 (1.17) | 7.57 (4.46-12.87) | <.001 | 18 (3.85) | 25.82 (16.07-41.49) | <.001 | 11 (9.91) | 70.63 (37.80-131.96) | <.001 |
| Uncomplicateda | 730 (0.09) | 6 (0.50) | 5.56 (2.49-12.45) | <.001 | 2 (0.43) | 4.74 (1.18-19.03) | .07 | 5 (4.51) | 52.30 (21.26-128.61) | <.001 |
| Alcohol use disorder | ||||||||||
| Total | 28 (<0.01) | 0 | 0.00 (NA) | >.99 | 1 (0.21) | 63.77 (8.65-470.28) | .02 | 2 (1.80) | 567.73 (133.12-2421.34) | <.001 |
| Uncomplicateda | 18 (<0.01) | 0 | 0.00 (NA) | >.99 | 1 (0.21) | 101.29 (13.45-762.65) | .01 | 1 (0.90) | 430.21 (56.76-3260.70) | .003 |
| Personality disorder | ||||||||||
| Total | 388 (0.05) | 12 (1.00) | 21.54 (12.09-38.37) | <.001 | 8 (1.71) | 36.79 (18.16-74.53) | <.001 | 5 (4.51) | 99.03 (40.16-244.20) | <.001 |
| Uncomplicateda | 294 (0.04) | 8 (0.67) | 18.82 (9.30-38.07) | <.001 | 4 (0.86) | 23.90 (8.87-64.37) | <.001 | 1 (0.90) | 24.95 (3.47-179.32) | .04 |
| Insomnia | ||||||||||
| Total | 3348 (0.42) | 13 (1.08) | 2.62 (1.52-4.54) | <.001 | 45 (9.62) | 25.79 (18.93-35.14) | <.001 | 12 (10.81) | 29.11 (15.97-53.05) | <.001 |
| Uncomplicateda | 2400 (0.30) | 4 (0.33) | 1.12 (0.42-2.98) | .79 | 8 (1.71) | 5.83 (2.89-11.74) | <.001 | 1 (0.90) | 3.04 (0.42-21.78) | .28 |
| Anxiety disorders | ||||||||||
| Total | 706 (0.09) | 2 (0.17) | 1.90 (0.47-7.62) | .28 | 5 (1.07) | 12.38 (5.11-29.97) | <.001 | 6 (5.41) | 65.62 (28.73-149.88) | <.001 |
| Uncomplicateda | 442 (0.06) | 1 (0.08) | 1.52 (0.21-10.80) | .48 | 3 (0.64) | 11.81 (3.78-36.90) | .002 | 3 (2.70) | 50.88 (16.09-160.84) | <.001 |
| Bipolar disorder | ||||||||||
| Total | 573 (0.07) | 7 (0.58) | 8.31 (3.93-17.55) | <.001 | 13 (2.78) | 41.00 (23.48-71.60) | <.001 | 7 (6.31) | 95.60 (44.28-206.43) | <.001 |
| Uncomplicateda | 236 (0.03) | 1 (0.08) | 2.85 (0.40-20.30) | .30 | 2 (0.43) | 14.74 (3.66-59.48) | .009 | 0 | 0.00 (NA) | >.99 |
| Adjustment disorder | ||||||||||
| Total | 528 (0.07) | 6 (0.50) | 7.72 (3.44-17.29) | <.001 | 5 (1.07) | 16.59 (6.85-40.22) | <.001 | 0 | 0.00 (NA) | >.99 |
| Uncomplicateda | 299 (0.04) | 2 (0.17) | 4.51 (1.12-18.13) | .07 | 3 (0.64) | 17.52 (5.60-54.83) | <.001 | 0 | 0.00 (NA) | >.99 |
| Previous suicide attempt | 651 (0.08) | 29 (2.40) | 31.91 (21.89-46.51) | <.001 | 6 (1.28) | 16.18 (7.20-36.33) | <.001 | 12 (10.81) | 152.49 (83.34-278.99) | <.001 |
| No. of coexisting psychiatric conditions | ||||||||||
| 6 | 2 (<0.01) | 0 | NA | NA | 0 | NA | NA | 0 | NA | NA |
| 5 | 8 (<0.01) | 0 | NA | NA | 0 | NA | NA | 0 | NA | NA |
| 4 | 60 (0.01) | 1 (0.08) | NA | NA | 2 (0.43) | NA | NA | 2 (1.80) | NA | NA |
| 3 | 291 (0.04) | 6 (0.50) | NA | NA | 14 (2.99) | NA | NA | 5 (4.51) | NA | NA |
| 2 | 1141 (0.14) | 12 (1.00) | NA | NA | 36 (7.69) | NA | NA | 10 (9.01) | NA | NA |
| 1 | 5721 (0.71) | 32 (2.66) | NA | NA | 45 (9.62) | NA | NA | 14 (12.61) | NA | NA |
| No mental condition | 797 394 (99.10) | 1151 (95.76) | 0.20 (0.15-0.27) | <.001 | 371 (79.27) | 0.03 (0.03-0.04) | <.001 | 80 (72.07) | 0.02 (0.02-0.04) | <.001 |
| Used psychiatric drugs | ||||||||||
| Antidepressants (total) | 4498 (0.56) | 23 (1.91) | NA | NA | 82 (17.52) | NA | NA | 19 (17.12) | NA | NA |
| TCA | 439 (0.06) | 0 | NA | NA | 3 (0.64) | NA | NA | 4 (3.60) | NA | NA |
| SSRI | 2842 (0.35) | 15 (1.25) | NA | NA | 56 (11.97) | NA | NA | 11 (9.91) | NA | NA |
| SNRI | 847 (0.11) | 4 (0.33) | NA | NA | 21 (4.49) | NA | NA | 6 (5.41) | NA | NA |
| NaSSA | 678 (0.08) | 8 (0.67) | NA | NA | 19 (4.06) | NA | NA | 7 (6.31) | NA | NA |
| Other | 662 (0.08) | 2 (0.17) | NA | NA | 18 (3.85) | NA | NA | 4 (3.60) | NA | NA |
| Benzodiazepines | 8488 (1.06) | 34 (2.83) | NA | NA | 101 (21.58) | NA | NA | 30 (27.03) | NA | NA |
| Z-drugsb | 11 585 (1.44) | 35 (2.91) | NA | NA | 62 (13.25) | NA | NA | 20 (18.02) | NA | NA |
Abbreviations: NA, not applicable; NaSSA, noradrenergic and specific serotonergic antidepressant; OR, odds ratio; SNRI, serotonin-norepinephrine reuptake inhibitor; SSRI, selective serotonin reuptake inhibitor; TCA, tricyclic antidepressant; Z-drug, nonbenzodiazepine γ-aminobutyric acid receptor agonist.
a
Cases without other coexisting psychiatric conditions.
b
Zolpidem, zopiclone, and eszopiclone.