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. 2023 Jan 7;12(2):257. doi: 10.3390/cells12020257

Figure 3.

Figure 3

Continuous infusion of endocan reduces the inflammatory response and improves the pulmonary physiological function in Esm1−/− mice. The inflammatory response on day 5 after intratracheal instillation of LPS in Esm1−/− mice treated over 3 days by the continuous infusion of murine endocan (purple) compared to PBS (grey) and WT mice (red). BAL examinations are shown with absolute numbers of leukocytes (A), neutrophils (B), and macrophages (C). mMPO BAL concentrations are shown in (D), mTNF BAL concentrations are shown in (E), and protein BAL concentrations are shown in (F). Transcutaneous oximetry measurements at different times are shown in (G). The serum concentration of endocan at D0 is shown in (H). Data are represented by their median, 25th, and 75th percentile. ∆ is equal to the estimation of the effect of the group according to the linear mixed model test. * represents a p < 0.05 as the result of the Mann–Whitney test between the variables of each group at a specific timing.