Table 1.

A collection of bioinformatic tools for antigen prediction.

Tool	Function	Method	Reference
VaxiJen v2.0	Prediction of protective antigens and subunit vaccines	Sequence-based	[100]
BepiPred 3.0	Prediction of potential B-cell epitopes	Sequence-based	[101]
DiscoTope 2.0 IEDB	Prediction of potential B-cell epitopes	Structure-based	[102]
ElliPro IEDB	B cell epitope prediction, based on solvent-accessibility and flexibility	Structure-based	[103]
SVMTriP	Prediction of protein regions preferentially recognised by antibodies	Sequence-based	[104]
Peptide binding to MHC class I molecules IEDB	MHC Class I epitope prediction	Sequence-based	[105]
Peptide binding to MHC class II molecules IEDB	MHC Class II epitope prediction	Sequence-based	[106]
NetMHCpan4.1 NetMHCIIpan4.0	Prediction of CD8 and CD4 T cell epitopes	Sequence-based	[107]
AllergenFP v.1.0 AllerTop v.2.0	Allergenicity prediction	Sequence-based	[108,109]
ToxinPred	Toxicity prediction	Sequence-based	[110]
Clustal Omega	Multiple sequence alignment using seeded guide trees and HMM profile-profile analysis	Sequence-based	[111]