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. 2023 Jan 11;12(2):277. doi: 10.3390/cells12020277

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Evolutionarily conserved lys-270 and lys-277 distinguish Hsp90α from Hsp90β for having important extracellular functions. (A) The dual lysine motif is essential for the extracellular and ATPase-independent functions of eHsp90α. Substitutions of G262 and T269 in Hsp90β with lysine grant Hsp90β similar extracellular functions to eHsp90α. The dual K270/K277 motif in human Hsp90α (B) and the corresponding G262/T260 motif in human Hsp90β (C) are evolutionarily conserved in all the Hsp90α subfamily and the Hsp90β subfamily members, respectively.