Skip to main content
. 2023 Jan 3;80(3):233–243. doi: 10.1001/jamaneurol.2022.4782

Table 4. Prespecified Sensitivity Analyses.

Subgroup Total, No. Association of DOAC intake with sICH <36 h, adjusted OR (95% CI) P value
Geographical region
Europe 474 0.60 (0.35-1.03) .07
Asia 209 0.63 (0.23-1.74) .37
Australia and New Zealand 149 0.34 (0.04-2.67) .31
Standard Operating Procedure available at the study center
Yes 729 0.54 (0.32-0.93) .03
No 103 1.19 (0.37-3.83) .77
Documented DOAC plasma levels >100 ng/mL or proven ingestion <12 h before IVT
Yes 252 0.57 (0.23-1.42) .23
No 580 0.57 (0.33-0.98) .04

Abbreviations: DOAC, direct oral anticoagulant; IVT, intravenous thrombolysis; OR, odds ratio; sICH, symptomatic intracranial hemorrhage.