Table 4. Prespecified Sensitivity Analyses.
| Subgroup | Total, No. | Association of DOAC intake with sICH <36 h, adjusted OR (95% CI) | P value |
|---|---|---|---|
| Geographical region | |||
| Europe | 474 | 0.60 (0.35-1.03) | .07 |
| Asia | 209 | 0.63 (0.23-1.74) | .37 |
| Australia and New Zealand | 149 | 0.34 (0.04-2.67) | .31 |
| Standard Operating Procedure available at the study center | |||
| Yes | 729 | 0.54 (0.32-0.93) | .03 |
| No | 103 | 1.19 (0.37-3.83) | .77 |
| Documented DOAC plasma levels >100 ng/mL or proven ingestion <12 h before IVT | |||
| Yes | 252 | 0.57 (0.23-1.42) | .23 |
| No | 580 | 0.57 (0.33-0.98) | .04 |
Abbreviations: DOAC, direct oral anticoagulant; IVT, intravenous thrombolysis; OR, odds ratio; sICH, symptomatic intracranial hemorrhage.