Table 4. Diagnoses and Symptoms in 919 Patients Who Underwent Surgery >1 Year vs 4361 Patients Who Underwent Surgery ≤1 Year After Diagnosis of Primary Hyperparathyroidisma.
| Time and diagnosis | Patients, No. (%) after matching | OR (95% CI) | P valueb | |
|---|---|---|---|---|
| Surgery >1 y after diagnosis (n = 748) | Surgery ≤1 y after diagnosis (n = 748) | |||
| 0 to ≤1 y | ||||
| Osteopenia or osteoporosis | 277 (37.0) | 299 (40.0) | 0.88 (0.72-1.09) | .24 |
| Fractures | 42 (5.6) | 36 (4.8) | 1.18 (0.75-1.86) | .49 |
| Urolithiasis | 109 (14.6) | 131 (17.5) | 0.80 (0.61-1.06) | .12 |
| MDD | 103 (13.8) | 154 (20.6) | 0.62 (0.47-0.81) | <.001 |
| Anxiety disorders | 80 (10.7) | 113 (15.1) | 0.67 (0.50-0.91) | .01 |
| HTN | 436 (58.3) | 471 (63.0) | 0.82 (0.67-1.01) | .06 |
| GERD | 154 (20.6) | 235 (31.4) | 0.57 (0.45-0.72) | <.001 |
| Malaise or fatigue | 112 (15.0) | 137 (18.3) | 0.79 (0.60-1.03) | .08 |
| Joint pain or myalgias | 191 (25.5) | 200 (26.7) | 0.94 (0.75-1.18) | .60 |
| Constipation | 62 (8.3) | 97 (13.0) | 0.61 (0.43-0.85) | .003 |
| Insomnia | 48 (6.4) | 40 (5.3) | 1.21 (0.79-1.87) | .38 |
| Polyuria | 58 (7.8) | 54 (7.2) | 1.08 (0.74-1.59) | .69 |
| Weakness | 67 (9.0) | 74 (9.9) | 0.90 (0.63-1.27) | .54 |
| Abdominal pain | 124 (16.6) | 108 (14.4) | 1.18 (0.89-1.56) | .25 |
| Headache | 40 (5.3) | 68 (9.1) | 0.57 (0.38-0.85) | .005 |
| Nausea | 40 (5.3) | 48 (6.4) | 0.82 (0.54-1.27) | .38 |
| Amnesia | 42 (5.6) | 58 (7.8) | 0.71 (0.47-1.07) | .10 |
| Gallstones | 18 (2.4) | 21 (2.8) | 0.85 (0.45-1.62) | .63 |
| 366 d to ≤2 y | ||||
| Osteopenia or osteoporosis | 258 (34.5) | 210 (28.1) | 1.35 (1.08-1.68) | .007 |
| Fractures | 33 (4.4) | 22 (2.9) | 1.52 (0.88-2.64) | .13 |
| Urolithiasis | 90 (12.0) | 65 (8.7) | 1.44 (1.03-2.01) | .03 |
| MDD | 114 (15.2) | 104 (13.9) | 1.11 (0.84-1.48) | .46 |
| Anxiety disorders | 89 (11.9) | 75 (10.0) | 1.21 (0.88-1.68) | .25 |
| HTN | 441 (59.0) | 353 (47.2) | 1.61 (1.31-1.97) | <.001 |
| GERD | 185 (24.7) | 138 (18.4) | 1.45 (1.13-1.86) | .003 |
| Malaise or fatigue | 96 (12.8) | 75 (10.0) | 1.32 (0.96-1.82) | .09 |
| Joint pain or myalgias | 175 (23.4) | 148 (19.8) | 1.24 (0.97-1.59) | .09 |
| Constipation | 69 (9.2) | 42 (5.6) | 1.71 (1.15-2.54) | .008 |
| Insomnia | 32 (4.3) | 37 (4.9) | 0.86 (0.53-1.39) | .54 |
| Polyuria | 57 (7.6) | 36 (4.8) | 1.63 (1.06-2.51) | .02 |
| Weakness | 49 (6.6) | 30 (4.0) | 1.68 (1.05-2.67) | .03 |
| Abdominal pain | 108 (14.4) | 83 (11.1) | 1.35 (1.00-1.84) | .05 |
| Headache | 53 (7.1) | 37 (4.9) | 1.47 (0.95-2.26) | .08 |
| Nausea | 42 (5.6) | 28 (3.7) | 1.53 (0.94-2.50) | .09 |
| Amnesia | 28 (3.7) | 28 (3.7) | 1.00 (0.59-1.71) | >.99 |
| Gallstones | 19 (2.5) | 14 (1.9) | 1.37 (0.68-2.75) | .38 |
| 731 d to ≤3 y | ||||
| Osteopenia or osteoporosis | 288 (38.5) | 181 (24.2) | 1.96 (1.57-2.75) | <.001 |
| Fractures | 23 (3.1) | 28 (3.7) | 0.82 (0.47-1.43) | .48 |
| Urolithiasis | 72 (9.6) | 63 (8.4) | 1.16 (0.81-1.65) | .42 |
| MDD | 106 (14.2) | 96 (12.8) | 1.12 (0.83-1.51) | .45 |
| Anxiety disorders | 88 (11.8) | 81 (10.8) | 1.10 (0.80-1.51) | .57 |
| HTN | 433 (57.9) | 361 (48.3) | 1.47 (1.20-1.81) | <.001 |
| GERD | 161 (21.5) | 148 (19.8) | 1.11 (0.87-1.43) | .41 |
| Malaise or fatigue | 92 (12.3) | 74 (9.9) | 1.28 (0.92-1.77) | .14 |
| Joint pain or myalgias | 194 (25.9) | 160 (21.4) | 1.29 (1.01-1.64) | .04 |
| Constipation | 56 (7.5) | 39 (5.2) | 1.47 (0.97-2.24) | .07 |
| Insomnia | 39 (5.2) | 35 (4.7) | 1.12 (0.70-1.79) | .63 |
| Polyuria | 43 (5.7) | 44 (5.9) | 0.98 (0.63-1.51) | .91 |
| Weakness | 47 (6.3) | 32 (4.3) | 1.50 (0.95-2.38) | .08 |
| Abdominal pain | 88 (11.8) | 66 (8.8) | 1.38 (0.98-1.93) | .06 |
| Headache | 43 (5.7) | 46 (6.1) | 0.93 (0.61-1.43) | .74 |
| Nausea | 28 (3.7) | 36 (4.8) | 0.77 (0.46-1.27) | .31 |
| Amnesia | 29 (3.9) | 28 (3.7) | 1.04 (0.61-1.76) | .89 |
| Gallstones | 16 (2.1) | 16 (2.1) | 1.00 (0.50-2.02) | >.99 |
| 1-3 y | ||||
| Osteopenia or osteoporosis | 362 (48.4) | 257 (34.4) | 1.79 (1.46-2.21) | <.001 |
| Fractures | 46 (6.1) | 40 (5.3) | 1.16 (0.75-1.79) | .51 |
| Urolithiasis | 114 (15.2) | 88 (11.8) | 1.35 (1.00-1.82) | .05 |
| MDD | 149 (19.9) | 136 (18.2) | 1.12 (0.87-1.45) | .39 |
| Anxiety disorders | 130 (17.4) | 113 (15.1) | 1.18 (0.90-1.56) | .23 |
| HTN | 496 (66.3) | 407 (54.4) | 1.65 (1.34-2.03) | <.001 |
| GERD | 234 (31.3) | 191 (25.5) | 1.33 (1.06-1.66) | .01 |
| Malaise or fatigue | 155 (20.7) | 122 (16.3) | 1.34 (1.03-74) | .03 |
| Joint pain or myalgias | 280 (37.4) | 234 (31.3) | 1.31 (1.06-1.63) | .01 |
| Constipation | 104 (13.9) | 63 (8.4) | 1.76 (1.26-2.45) | <.001 |
| Insomnia | 54 (7.2) | 58 (7.8) | 0.93 (0.63-1.36) | .69 |
| Polyuria | 88 (11.8) | 67 (9.0) | 1.36 (0.97-1.90) | .07 |
| Weakness | 86 (11.5) | 55 (7.4) | 1.64 (1.15-2.33) | .006 |
| Abdominal pain | 162 (21.7) | 127 (17.0) | 1.35 (1.04-1.75) | .02 |
| Headache | 87 (11.6) | 71 (9.5) | 1.26 (0.90-1.73) | .18 |
| Nausea | 66 (8.8) | 56 (7.5) | 1.20 (0.83-1.73) | .34 |
| Amnesia | 47 (6.3) | 45 (6.0) | 1.05 (0.69-1.60) | .83 |
| Gallstones | 30 (4.0) | 23 (3.1) | 1.31 (0.76-2.29) | .33 |
Abbreviations: GERD, gastroesophageal reflux disease; HTN, hypertension; MDD, major depressive disorder; OR, odds ratio.
a
Note that 1398 patients were excluded from this analysis because they did not have follow-up 3 years after diagnosis.
b
Statistical significance is defined as P < .003.