TABLE 1.
Effect of intranasal immunization on the nasopharyngeal colonization of mice by serotype 6B pneumococci
| Immunogen | Results when challenged 2 wk post-immunizations
|
|
|---|---|---|
| No. colonized/total no. (% colonized) | P vs controla | |
| Without adjuvant | ||
| Control (saline alone) | 39/44 (85) | —b |
| Live serotype 6B | 0/10 (0) | <0.0001 |
| Live serotype 14 | 5/12 (42) | 0.0017 |
| Live serotype 10 | 5/12 (42) | 0.0017 |
| Killed Rx1AL− | 8/11 (72) | 0.33 |
| With adjuvant (CT) | ||
| Control (CT alone) | 10/22 (45) | —b |
| Killed Rx1AL− + CT | 0/29 (0) | <0.0001 |
a
P values were calculated by the Fisher exact test.
b
P = 0.002 for comparison between groups that received CT versus saline alone.