Figure 2. Adjusted Analysis Comparing 3-Month Functional Outcomes in the Intervention vs Attention Control Arm Stratified by Baseline Frailty Status.

Adjusted measures of Short Physical Performance Battery (SPPB) score at 3-month follow-up, relative changes in SPPB from baseline to 3-month follow-up, and adjusted measures of Kansas City Cardiomyopathy Questionnaire (KCCQ) score and 6-minute walk distance at 3-month follow-up among intervention and attention control group participants stratified by frail and prefrail status at baseline. Follow-up data are presented as least-squares means with SEs adjusted for baseline value, clinical site, age, sex, and ejection fraction category. Effect size represents the difference in least-squares means between the intervention and attention control groups. P for interaction (prefrail vs frail × intervention arm) was significant for SPPB score and percentage change in SPPB score but was nonsignificant for all other outcomes. Error bars indicate 95% CIs.