Figure 2. Risk of Psychiatric Disorders for Spouses of Patients With Cancer Among Spouses With or Without Preexisting Psychiatric Comorbidity vs Spouses of Individuals Without Cancer.

Hazard ratios (HRs) were estimated from Cox models, adjusting for sex, age at cohort entry, calendar year at cohort entry, country of residence, household income, and history of cancer. A, Estimates of first-onset diagnosis of any psychiatric disorder, substance abuse, depression, anxiety, and stress-related disorder among spouses of patients with cancer (exposed group) and spouses of individuals without cancer (matched unexposed group) who had no preexisting psychiatric morbidity. B, All spouses in the exposed and unexposed groups who had previous psychiatric disorders before cohort entry were included and followed up for first hospital visit for any psychiatric disorders, newly or previously diagnosed. Only spouses with a previous psychiatric disorder other than substance use, depression, anxiety, or stress-related disorders were then included and followed up for first-onset of substance abuse, depression, anxiety, or stress-related disorders separately. IR indicates incidence rate; NA, not applicable.