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. 2022 Dec 28;158(2):192–202. doi: 10.1001/jamasurg.2022.6697

Table 2. Coefficients and Standard Errors of the Cox Prediction Modela.

Factor Estimated coefficient (SE)
Treatment sorafenib vs reoperative hepatectomy or thermoablation 6.59 (1.91)
Treatment chemoembolization vs reoperative hepatectomy or thermoablation 3.65 (2.03)
Female (age) 0.04 (0.02)
Cirrhosis: yes vs no 0.15 (0.29)
Female (No. of recurrence nodules): 1 −0.04 (0.65)
Female (No. of recurrence nodules): 2 7.80 (5.69)
Female (size recurrence nodules): 1 0.32 (0.17)
Female (size recurrence nodules): 2 0.85 (0.38)
Bilobar recurrence: yes vs no 0.63 (0.39)
Extrahepatic recurrence: yes vs no 1.02 (0.35)
Female (time to recurrence) 0.68 (0.24)
Sorafenib × female (age) −0.05 (0.02)
Chemoembolization × female (age) −0.02 (0.02)
Sorafenib × cirrhosis −0.30 (0.37)
Chemoembolization × cirrhosis 0.31 (0.40)
Sorafenib × female (No. of recurrence nodules): 1 −1.27 (0.89)
Chemoembolization × female (No. of recurrence nodules): 1 −0.86 (0.85)
Sorafenib × female (No. of recurrence nodules): 2 −4.89 (6.51)
Chemoembolization × female (No. of recurrence nodules): 2 −5.47 (6.68)
Female (No. of recurrence nodules): 1 × female (No. of recurrence nodules): 2 −0.15 (0.13)
Sorafenib × female (size recurrence nodules): 1 0.14 (0.12)
Chemoembolization × female (size recurrence nodules): 1 −0.06 (0.17)
Sorafenib × female (size recurrence nodules): 2 0.45 (0.39)
Chemoembolization × female (size recurrence nodules): 2 0.09 (0.61)
Female (size recurrence nodules): 1 × female (size recurrence nodules): 2 0.08 (0.04)
Sorafenib × bilobar recurrence −0.88 (0.51)
Chemoembolization × bilobar recurrence −0.87 (0.47)
Sorafenib × extrahepatic recurrence −0.62 (0.42)
Chemoembolization × extrahepatic recurrence 0.90 (0.57)
Sorafenib × female (time to recurrence) −0.38 (0.31)
Chemoembolization × female (time to recurrence) 0.16 (0.33)
a

All second-order interactions of the features with treatment are included.