Table 6.
Pharmacokinetic parameters of methotrexate from methotrexate-loaded nanoemulsion gel formulations upon administration to skin in rabbits up to 24 h.
| Parameters | FNEG2 | FNEG4 | FNEG6 |
|---|---|---|---|
| Cmax (µg/mL) | 8.1 ± 0.13 | 8.7 ± 0.34 | 9.1 ± 0.21 |
| Tmax (h) | 12 | 12 | 12 |
| K (h−1) | 0.040 ± 0.005 | 0.036 ± 0.003 | 0.031 ± 0.002 |
| t ½ | 14.9 ± 1.98 | 15.4 ± 2.14 | 15.8 ± 1.78 |
| AUC 0–t (µg/mL.h) | 159.2 ± 18.2 | 165.5 ± 19.6 | 173.8± 21.7 |
| MRT (h) | 11.69 ± 0.26 | 11.82 ± 0.19 | 12.10 ± 0.32 |
Cmax, peak plasma concentration of drug; Tmax, time at which Cmax was observed; K, elimination rate constant; t ½, elimination half-life; AUC 0–t, area under the plasma concentration time curve from 0 h to time t; MRT, mean residence time.