Table 7.
Storage stability of methotrexate nanoemulsion gel formulation (FNEG6) at refrigerated and accelerated temperatures for 60 days.
| Parameters | Temperature | |
|---|---|---|
| 4 ± 2 °C | 40 ± 2 °C | |
| Particle size | 24.76 ± 4.12 | 24.21 ± 3.98 |
| PDI | 0.29 ± 0.35 | 0.27 ± 0.19 |
| Zeta potential (mV) | −3.81 ± 4.21 | −3.86 ± 3.29 |
| pH | 6.14 ± 0.32 | 6.31 ± 0.16 |
| Phase separation | Nil | Nil |
| Clarity | Transparent and clear | Transparent and clear |
| Drug content (%) ± SD | 97.21 ± 0.32 | 97.10 ± 0.12 |
| Color change | No change | No change |
Data expressed as mean ± SD (n = 3).