Table 2.
Summary of the eligible studies applying NBI for detecting the malignant transformation of OPMD and OSCC.
| Author, year | Region | Mean Age | Sample type | Diagnostic criterion | Biopsy negative criterion | TP | FP | FN | TN | SEN (95%CI) | SPE (95%CI) | Quadas-II |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Shih-Wei Yang, 2011 (15) | China | 50.96 ± 10.25 | Oral Leukoplakia | histopathology | N | 101 | 4 | 10 | 50 | 0.910 (0.841,0.956) | 0.926 (0.821,0.979) | 7 |
| Shih-Wei Yang, 2011 (27) | China | 52.60 ± 10.86 | Oral Leukoplakia | histopathology | N | 25 | 6 | 26 | 103 | 0.490 (0.348,0.634) | 0.945 (0.884,0.980) | 7 |
| Shih-Wei Yang, 2012 (28) | China | 52.15 ± 10.75 | Oral Leukoplakia | histopathology | N | 180 | 31 | 60 | 137 | 0.750 (0.690,0.803) | 0.815 (0.748,0.871) | 7 |
| T. Shibahara, 2013 (31) | Japan | U | OSCC/OPMD | histopathology | N&L | 48 | 8 | 4 | 77 | 0.923 (0.815,0.979) | 0.906 (0.823,0.958) | 6 |
| Shih-Wei Yang, 2014 (29) | China | 57.9 ± 16.7 | Oral Chronic Non-healing Ulcers | histopathology | N&L | 15 | 4 | 1 | 43 | 0.938 (0.698,0.998) | 0.916 (0.796,0.976) | 7 |
| Shih-Wei Yang, 2015 (30) | China | 54.6 ± 11.2 | Oral Erythroplakia | histopathology | N | 60 | 6 | 0 | 6 | 1.000 (0.940,1.000) | 0.500 (0.211,0.789) | 7 |
| AN Vu, 2015 (21) | Australia | 58.58 ± 9.42 62.09 ± 11.12 | OPMD | histopathology | N | 60 | 20 | 8 | 5 | 0.882 (0.781,0.948) | 0.200 (0.068,0.407) | 7 |
| Giulia Ottaviani, 2016 (26) | Italy | U | OSCC | histopathology | N | 23 | 0 | 0 | 68 | 1.000 (0.852,1.000) | 1.000 (0.947,1.000) | 6 |
| Pizza C, 2016 (19) | Italy | 65 | OSCC/OPMD | histopathology | N | 80 | 6 | 10 | 32 | 0.889 (0.805,0.945) | 0.842 (0.804,0.871) | U |
| Aparaajita Upadhyay, 2019 (25) | India | U | Oral Malignant Lesions | histopathology | N | 31 | 0 | 6 | 1 | 0.838 (0.680,0.938) | 1.000 (0.025,1.000) | 5 |
| Agostino Guida, 2019 (22) | Italy | 61 ± 13.7 | OSCC/OPMD | histopathology | N | 59 | 19 | 7 | 11 | 0.894 (0.794,0.956) | 0.367 (0.199,0.561) | 6 |
| Alberto Deganello, 2020 (23) | Italy | 68 | Oral Lichen Planus | histopathology | N&L | 5 | 2 | 0 | 49 | 1.000 (0.478,1.000) | 0.961 (0.865,0.995) | 6 |
| Airi Ota, 2022 (32) | Jagan | U | OSCC/OPMD | histopathology | N | U | U | U | U | 1.000 (0.661,1.000) | 0.809 (0.667,0.909) | U |
NBI, narrow band imaging; OSCC, oral squamous cell carcinoma; OPMD, oral potentially malignant disorders; U, unknown; N, non-dysplasia; L, low-grade dysplasia; SEN, sensitivity; SPE, specificity; CI, confidence interval; TP, true positive; FP, false positive; TN, true negative; FN, false negative.