Table 2. Association Between Baseline HDL-C Level and at Least 1 Fracture Occurring After Recruitment.
| Analysis | HDL-C (continuous), HR (95% CI) | HDL-C quintiles, HR (95% CI) | ||
|---|---|---|---|---|
| Q1 | Q2-Q4 | Q5 | ||
| All participants (n = 16 264) | ||||
| IR per 1000 person-years (95% CI) | 26 (24-27) | 23 (21-25) | 25 (23-27) | 32 (29-36) |
| Model 1a | 1.15 (1.10-1.21) | 1 [Reference] | 1.10 (0.98-1.24) | 1.39 (1.20-1.60) |
| Model 2b | 1.15 (1.10-1.21) | 1 [Reference] | 1.07 (0.98-1.23) | 1.37 (1.19-1.58) |
| Model 3c | 1.15 (1.10-1.21) | 1 [Reference] | 1.10 (0.98-1.23) | 1.37 (1.19-1.59) |
| Model 4d | 1.14 (1.08-1.20) | 1 [Reference] | 1.09 (0.97-1.23) | 1.33 (1.14-1.54) |
| Analyses stratified by sexe | ||||
| Male (n = 7319) | ||||
| IR per 1000 person-years (95% CI) | 15 (14-17) | 14 (11-16) | 15 (13-17) | 21 (17-26) |
| Model 1a | 1.20 (1.09-1.33) | 1 [Reference] | 1.07 (0.85-1.34) | 1.48 (1.12-1.95) |
| Model 2b | 1.21 (1.10-1.34) | 1 [Reference] | 1.08 (0.86-1.36) | 1.51 (1.14-2.00) |
| Model 3c | 1.21 (1.10-1.34) | 1 [Reference] | 1.08 (0.86-1.36) | 1.52 (1.14-2.00) |
| Model 4d | 1.21 (1.09-1.35) | 1 [Reference] | 1.06 (0.83-1.35) | 1.45 (1.07-1.95) |
| Female (n = 8945) | ||||
| IR per 1000 person-years (95% CI) | 34 (32-36) | 30 (27-34) | 34 (32-37) | 42 (37-47) |
| Model 1a | 1.14 (1.08-1.20) | 1 [Reference] | 1.12 (0.98-1.28) | 1.35 (1.14-1.60) |
| Model 2b | 1.13 (1.07-1.20) | 1 [Reference] | 1.10 (0.96-1.26) | 1.33 (1.12-1.57) |
| Model 3c | 1.13 (1.07-1.19) | 1 [Reference] | 1.11 (0.96-1.27) | 1.33 (1.12-1.57) |
| Model 4d | 1.12 (1.06-1.19) | 1 [Reference] | 1.11 (0.96-1.28) | 1.29 (1.08-1.55) |
Abbreviations: HDL-C, high-density lipoprotein cholesterol; HR, hazard ratio; IR, incidence rate.
a
Model 1 was adjusted for age and sex.
b
Model 2 was adjusted for age, sex, physical activity, and alcohol use.
c
Model 3 was adjusted for age, sex, physical activity, alcohol use, and prefrailty/frailty status.
d
Model 4 was adjusted for age, sex, physical activity, alcohol use, prefrailty/frailty status, education, body mass index, smoking status, aspirin use, diabetes, chronic kidney disease, use of lipid-lowering medication, and use of antiosteoporosis medications.
e
Not adjusted for sex.