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. 2023 Jan 6;13:1050939. doi: 10.3389/fmicb.2022.1050939

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Copyright © 2023 Burgunter-Delamare, Rousvoal, Legeay, Tanguy, Fredriksen, Boyen and Dittami.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Analysis of samples with symptoms from Roscoff and Helgoland. (A) NMDS analysis of the microbiome composition. Results do not show a separation of the healthy and symptomatic samples (PERMANOVA p > 0.05). (B) Box plot of alpha-diversity (Shannon H index) across different sample types calculated at the ASV level. Error bars correspond to the range; n = 51, conditions do not differ significantly (Mann–Whitney pairwise test, p > 0.05). (C) Microbiome composition of healthy and symptoms samples at the phylum level. Bars show the relative abundance of 16S rRNA gene metabarcoding sequences; all phyla were detected in all sample types, and only their relative abundance varied. Proteobacteria_NA: unclassified Proteobacteria. (D) NMDS analysis of the microbiome composition depending on the symptoms.