Table 1.
Patient Characteristics by Fertility-Sparing Treatment and Cancer Type
| Sociodemographic and clinical characteristics | Cervical (n=4,521) | Endometrial (n=1,504) | Ovarian (n=1,711) | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Fertility-Sparing (n=850) | Not Fertility-Sparing (n=3,671) | P Value | Fertility-Sparing (n=108) | Not Fertility-Sparing (n=1,396) | P Value | Fertility-Sparing (n=741) | Not Fertility-Sparing (n=970) | P Value | |
| Age (years), n (%) | <0.01 | <0.01 | <0.01 | ||||||
| 18–35 | 573 (31.3) | 1,260 (68.7) | 66 (18.2) | 296 (81.8) | 552 (70.5) | 231 (29.5) | |||
| 36–45 | 277 (10.3) | 2,411 (89.7) | 42 (3.7) | 1,100 (96.3) | 189 (20.4) | 739 (79.6) | |||
| Diagnosis year, n (%) | <0.01 | 0.04 | 0.22 | ||||||
| 2000–2005 | 296 (16.4) | 1508 (83.6) | 17 (6.8) | 233 (93.2) | 255 (42.6) | 344 (57.4) | |||
| 2006–2010 | 292 (19.5) | 1208 (80.5) | 32 (5.3) | 571 (94.7) | 229 (41.2) | 327 (58.8) | |||
| 2011–2015 | 262 (21.5) | 955 (78.5) | 59 (9.1) | 592 (90.9) | 257 (46.2) | 299 (53.8) | |||
| SES, n (%) | <0.01 | 0.52 | 0.96 | ||||||
| Lowest | 160 (17.8) | 738 (82.2) | 24 (7.2) | 309 (92.8) | 106 (42.1) | 146 (57.9) | |||
| Lower-middle | 154 (16.5) | 780 (83.5) | 21 (5.6) | 355 (94.4) | 151 (43.8) | 194 (56.2) | |||
| Middle | 156 (16.7) | 778 (83.5) | 20 (6.8) | 274 (93.2) | 165 (44.7) | 204 (55.3) | |||
| Upper-middle | 206 (20.6) | 794 (79.4) | 26 (8.2) | 293 (91.8) | 163 (43.1) | 215 (56.9) | |||
| Highest | 174 (23.0) | 581 (77.0) | 17 (9.3) | 165 (90.7) | 156 (42.5) | 211 (57.5) | |||
| Charlson comorbidity score, n (%) | <0.01 | <0.01 | 0.01 | ||||||
| Score=0 | 621 (16.6) | 3121 (83.4) | 70 (6.8) | 966 (93.2) | 648 (44.4) | 813 (55.6) | |||
| Score≥1 | 63 (14.0) | 386 (86.0) | 22 (5.2) | 399 (94.8) | 70 (33.8) | 137 (66.2) | |||
| Unknown | 166 (50.3) | 164 (49.7) | 16 (34.0) | 31 (66.0) | 23 (53.5) | 20 (46.5) | |||
| Insurance, n (%) | 0.01 | 0.31 | 0.92 | ||||||
| Public | 162 (15.5) | 880 (84.5) | 21 (9.5) | 199 (90.5) | 110 (44.5) | 137 (55.5) | |||
| Private | 558 (19.4) | 2313 (80.6) | 74 (6.9) | 997 (93.1) | 519 (42.8) | 694 (55.6) | |||
| Uninsured/self-pay | 28 (24.6) | 86 (75.4) | * | * | 25 (45.5) | 30 (54.5) | |||
| Other or unknown | 102 (20.6) | 392 (79.4) | 11 (7.4) | 137 (92.6) | 87 (44.4) | 109 (55.6) | |||
| Marital status, n (%) | <0.01 | 0.34 | <0.01 | ||||||
| Single | 397 (26.9) | 1079 (73.1) | 49 (8.8) | 510 (91.2) | 396 (53.4) | 345 (46.6) | |||
| Married | 337 (14.0) | 2064 (86.0) | 49 (6.2) | 738 (93.8) | 283 (34.7) | 532 (65.3) | |||
| Other† | 68 (13.8) | 425 (86.2) | * | * | 45 (39.1) | 70 (60.9) | |||
| Unknown | 48 (31.8) | 103 (68.2) | * | * | 17 (42.5) | 23 (57.5) | |||
| Race or ethnicity, n (%) | <0.01 | 0.01 | <0.01 | ||||||
| American Indian | * | * | * | * | * | * | |||
| Asian or Pacific Islander | 110 (22.1) | 388 (77.9) | 34 (11.4) | 263 (88.6) | 161 (43.8) | 207 (56.3) | |||
| Hispanic | 246 (15.4) | 1348 (84.6) | 44 (6.9) | 597 (93.1) | 262 (49.0) | 273 (51.0) | |||
| Non-Hispanic Black | 46 (19.3) | 192 (80.7) | * | * | 46 (53.5) | 40 (46.5) | |||
| Non-Hispanic White | 416 (19.8) | 1688 (80.2) | 22 (4.5) | 464 (95.5) | 264 (37.3) | 444 (62.7) | |||
| None of the above | 23 (50.0) | 23 (50.0) | 0 (0.0) | 10 (100.0) | * | * | |||
| Rurality, n (%) | 0.02 | 0.67 | <0.01 | ||||||
| Rural | 91 (15.2) | 506 (84.8) | 11 (6.4) | 161 (93.6) | 49 (29.2) | 119 (70.8) | |||
| Urban | 759 (19.3) | 3165 (80.7) | 97 (7.3) | 1235 (92.7) | 692 (44.8) | 851 (55.2) | |||
| Parity, n (%)‡ | <0.01 | 0.22 | 0.19 | ||||||
| 0 | 632 (19.6) | 2590 (80.4) | 102 (7.4) | 1276 (92.6) | 597 (43.2) | 785 (56.8) | |||
| 1 | 89 (31.2) | 196 (68.8) | * | * | 64 (50.0) | 64 (50.0) | |||
| ≥2 | 129 (12.7) | 883 (87.3) | * | * | 80 (39.8) | 121 (60.2) | |||
| Cancer stage, n (%) | <0.01 | <0.01 | <0.01 | ||||||
| 1A | 641 (30.4) | 1469 (69.6) | 66 (6.3) | 987 (93.7) | 545 (47.0) | 614 (53.0) | |||
| 1B | 209 (8.7) | 2202 (91.3) | * | * | NA | NA | |||
| 1C | NA | NA | NA | NA | 196 (35.5) | 356 (64.5) | |||
| 1, unknown | NA | NA | 38 (18.7) | 165 (81.3) | NA | NA | |||
| Histology, n (%)§ | <0.01 | 0.08 | <0.01 | ||||||
| Adenocarcinoma | 215 (15.7) | 1158 (84.3) | 23 (9.9) | 210 (90.1) | NA | NA | |||
| Adenosquamous carcinoma | 15 (6.9) | 201 (93.1) | NA | NA | NA | NA | |||
| Squamous carcinoma | 577 (21.5) | 2110 (78.5) | NA | NA | NA | NA | |||
| Endometrioid adenocarcinoma | NA | NA | 85 (6.7) | 1186 (93.3) | NA | NA | |||
| Germ cell | NA | NA | NA | NA | 246 (74.5) | 84 (25.5) | |||
| Sex cord stromal | NA | NA | NA | NA | 50 (50.0) | 50 (50.0) | |||
| Epithelial | NA | NA | NA | NA | 445 (34.7) | 836 (65.3) | |||
| None of the above | 43 (17.6) | 202 (82.4) | 0 (0.0 | 0 (0.0) | 0 (0.0) | 0 (0.0) | |||
| Chemotherapy, n (%) | <0.01 | 1.00 | <0.01 | ||||||
| Yes | 47 (9.6) | 444 (90.4) | *) | * | 245 (35.8) | 440 (64.2) | |||
| No | 799 (19.9) | 3,216 (80.1) | 107 (7.2) | 1370 (92.7) | 482 (48.7) | 508 (51.3) | |||
| Unknown | * | * | * | * | 14 (38.9) | 22 (61.1) | |||
| Radiotherapy, n (%)‡ | <0.01 | 0.25 | 0.84 | ||||||
| Yes | 61 (8.2) | 682 (91.8) | 0 (0.0) | 26 (100.0) | * | * | |||
| No | 789 (20.9) | 2,988 (79.1) | 108 (7.3) | 1370 (92.7) | 739 (43.4) | 965 (56.6) | |||
| Hormonal therapy, n (%)‡ | 0.20 | <0.01 | 0.72 | ||||||
| Yes | * | * | 108 (100.0) | 0 (0.0) | * | * | |||
| No | 848 (18.8) | 3,656 (81.2) | 0 (0.0) | 1393 (100.0) | 736 (43.3) | 965 (56.7) | |||
Abbreviations: SES, socioeconomic status, NA, not applicable.
Cells are n (row percentage). P values were calculated by chi-squared and Fisher’s exact tests.
*
Values are not shown to protect confidentiality of the individuals summarized in the data.
†
”Other” marital status included separated, divorced, widowed, unmarried, or in a domestic partnership.
‡
There were 2 unknown cases of parity, 2 unknown cases of radiotherapy, and 4 unknown cases of hormonal therapy among patients who received non-fertility sparing treatment in the dataset. These rows were excluded from the table for conciseness.
§
Specific histology codes are listed in Appendix 2 (http://links.lww.com/xxx).