Table 1.
Patients’ characteristics summary statistics a by VAIN grade at diagnosis.
| Characteristic | Category | VAIN Grade | ||||
|---|---|---|---|---|---|---|
| All Patients n = 255 |
VAIN 1 n = 52 |
VAIN 2 n = 55 |
VAIN 3 n = 148 |
p-Value | ||
| Age (years) at first diagnosis | 52.4 (12.8) | 51.4 (12.2) | 50.1 (13.4) | 53.7 (12.7) | 0.18 | |
| Current/former smoker | 86 (34.1) | 18 (34.6) | 27 (50.9) | 41 (27.9) | 0.01 | |
| Parity | 129 (55.4) | 21 (42.9) | 21 (46.7) | 87 (62.6) | 0.02 | |
| Immunosuppression | 29 (11.5) | 5 (9.6) | 5 (9.1) | 19 (13.0) | 0.77 | |
| Hormonal therapy | 40 (15.7) | 8 (15.4) | 7 (12.7) | 25 (16.9) | 0.82 | |
| Previous hysterectomy | CIN2+ | 97 (38.0) | 13 (25.0) | 17 (30.9) | 67 (45.3) | |
| Other | 14 (5.5) | 3 (5.8) | 6 (10.9) | 5 (3.4) | ||
| No hysterectomy | 144 (56.5) | 36 (69.2) | 32 (58.2) | 76 (51.4) | 0.02 | |
| Previous cervical cancer | Yes | 56 (22.1) | 12 (23.5) | 6 (10.9) | 38 (25.9) | |
| No/Other tumors b | 197 (77.9) | 39 (76.5) | 49 (89.1) | 109 (74.2) | 0.06 | |
| Previous CIN | No/CIN1 | 150 (59.3) | 33 (63.5) | 31 (56.4) | 86 (58.9) | |
| CIN2-3 | 103 (40.7) | 19 (44.7) | 24 (43.6) | 60 (41.1) | 0.75 | |
| Concomitant CIN | No/CIN1 | 224 (87.8) | 48 (92.3) | 47 (85.5) | 129 (87.2) | |
| CIN2-3 | 31 (12.2) | 4 (7.7) | 8 (14.6) | 19 (12.8) | 0.52 | |
| Previous VIN | No | 232 (91.7) | 47 (92.2) | 51 (92.7) | 134 (91.2) | |
| VIN3 | 21 (8.3) | 4 (7.8) | 4 (7.3) | 13 (8.8) | 1.00 | |
| Concomitant VIN | No | 233 (91.4) | 48 (92.3) | 51 (92.7) | 134 (90.5) | |
| VIN1 | 4 (1.6) | 2 (3.9) | 0 | 2 (1.4) | ||
| VIN2 | 1 (0.4) | 0 | 1 (1.8) | 0 | ||
| VIN3 | 17 (6.7) | 2 (3.9) | 3 (5.5) | 12 (8.1) | 0.34 | |
| Previous AIN | No | 247 (97.6) | 49 (96.1) | 53 (96.4) | 145 (98.6) | |
| AIN2 | 1 (0.4) | 0 | 1 (1.8) | 0 | ||
| AIN3 | 5 (2.0) | 2 (3.9) | 1 (1.8) | 2 (1.4) | 0.28 | |
| Concomitant AIN | No | 253 (99.6) | 51 (98.1) | 54 (100) | 148 (100) | |
| AIN1 | 1 (0.4) | 1 (1.9) | 0 | 0 | 0.20 | |
| HR-HPV | HR+ with 16 and/or 18 | 71 (44.4) | 11 (30.6) | 14 (36.8) | 46 (53.5) | |
| HR+ without 16 and 18 | 63 (39.4) | 14 (36.8) | 20 (52.6) | 26 (30.2) | ||
| Negative | 26 (16.3) | 8 (22.2) | 4 (10.5) | 14 (16.3) | 0.05 | |
| Cytology | Negative | 7 (3.1) | 2 (4.1) | 2 (4.0) | 3 (2.3) | |
| ASCUS-LSIL | 67 (29.3) | 29 (59.2) | 15 (30.0) | 23 (17.7) | ||
| ASCH-HSIL | 145 (63.3) | 17 (34.7) | 33 (66.0) | 95 (73.1) | ||
| SCC | 10 (4.4) | 1 (2.0) | 0 | 9 (6.9) | <0.001 | |
an (column %) for categorical variable, Mean (SD) for Age; SD = Standard deviation; b including 153 women with no history of any cancer and 44 women with a previous history of other non-HPV-related tumors (i.e., breast cancer, Hodgkin’s lymphoma, colorectal cancer, endometrial cancer); VAIN = Vaginal Intraepithelial Neoplasia; CIN = Cervical Intraepithelial Neoplasia; VIN = Vulvar Intraepithelial Neoplasia; AIN = Anal Intraepithelial Neoplasia; HR-HPV = High-risk Human Papillomavirus; ASCUS = Atypical Squamous Cells of Undetermined Significance; LSIL = Low Squamous Intraepithelial Lesion; ASCH = Atypical Squamous Cells cannot exclude HSIL; HSIL = High Squamous Intraepithelial Lesion; SCC = Squamous Cell Carcinoma.