Table 4.
Multivariate analysis of variance of risk factors for VAIN excluding lesion type and vascularity.
| VAIN Grade | Factor | Level | OR (95% CI) | p-Value |
|---|---|---|---|---|
| VAIN2 vs. VAIN1 | Smoking | No | Ref | |
| Yes | 1.53 (0.62,3.78) | 0.36 | ||
| Previous hysterectomy | No hysterectomy | Ref | ||
| CIN2+ | 1.20 (0.43,3.38) | 0.73 | ||
| Other | 1.11 (0.19,6.50) | 0.91 | ||
| Colposcopic Grade | G1 | Ref | ||
| G2 | 4.77 (1.40,16.2) | 0.01 | ||
| VAIN3 a vs. VAIN1 | Smoking | No | Ref | |
| Yes | 0.61 (0.25,1.47) | 0.27 | ||
| Previous hysterectomy | No hysterectomy | Ref | ||
| CIN2+ | 2.15 (0.89,5.24) | 0.09 | ||
| Other | 1.46 (0.28,7.64) | 0.66 | ||
| Colposcopic Grade | G1 | Ref | ||
| G2 | 20.4 (6.67,61.4) | <0.001 |
a Including n = 10 VAIN3 with stromal microinvasion; VAIN = Vaginal Intraepithelial Neoplasia; OR = Odds Ratio; CI = Confidence Interval; CIN = Cervical Intraepithelial Neoplasia; G = Grade.