Table 5. Comparison of executive function scores between 11p15 LOM and control groups.
| 11p15 LOM group | Control group | BF+0 | BF-0 | W | |
|---|---|---|---|---|---|
| (N = 16) | (N = 19) | ||||
| Mean (SD) | Mean (SD) | ||||
| d2-R | |||||
| Processing speed | 145.00 (33.26)a | 154.53 (27.05) | 0.73 | 174.00 | |
| Sustained attention/concentration | 132.60 (34.87)a | 145.26 (24.26) | 1.04 | 182.50 | |
| Accuracy | 8.76 (8.45)a | 5.76 (3.87) | 1.06 | 115.00 | |
| Omission errors | 11.40 (11.61)a | 9.11 (6.81) | 0.59 | 130.00 | |
| Commission errors | 0.93 (1.10)a | 0.16 (0.50) | 2.97 | 80.50 | |
| Digit span subtest | |||||
| Span backward | 4.50 (1.71) | 4.89 (1.20) | 0.85 | 190.00 | |
| Trail Making Test | |||||
| Time Part A | 37.88 (13.25) | 26.79 (7.71) | 5.02 | 76.50 | |
| Time Part B | 85.19 (43.49) | 63.68 (18.27) | 1.47 | 109.00 | |
| Time Part B-A | 47.31 (35.59) | 36.89 (14.93) | 0.39 | 149.00 | |
| Stroop | |||||
| Interference time | 43.56 (21.45) | 42.00 (14.20) | 0.28 | 168.00 | |
| Verbal fluency | |||||
| Letter p | 21.00 (6.36) | 23.16 (5.05) | 0.72 | 176.00 | |
| Animal category | 32.31 (8.56) | 32.21 (6.36) | 0.43 | 166.00 | |
| Modified Sorting Card Test | |||||
| Categories completed | 5.75 (0.45) | 5.74 (0.56) | 0.36 | 156.00 | |
| Total errors | 9.00 (3.98) | 9.26 (4.25) | 0.28 | 157.00 | |
| Perseverative errors | 1.31 (2.65) | 1.16 (1.50) | 0.25 | 174.00 | |
| BRIEF/BRIEF-A questionnaire | |||||
| Behavioral Regulation Index | 47.06 (7.54) | 50.35 (10.86)b | 0.20 | 153.50 | |
| Metacognition Index | 50.31 (11.72) | 48.24 (10.70) b | 0.37 | 129.00 | |
| Global Executive Composite | 48.75 (9.15) | 48.88 (10.55) b | 0.32 | 128.00 | |
| Inhibit subscale | 46.63 (5.18) | 48.76 (11.33) b | 0.31 | 138.50 | |
| Shift subscale | 49.75 (9.62) | 52.12 (12.25) b | 0.25 | 146.50 | |
| Working memory subscale | 51.19 (11.55) | 47.41 (8.86) b | 0.60 | 117.00 | |
| Plan/Organize subscale | 50.31 (10.35) | 48.88 (10.82) b | 0.45 | 125.50 |
Note. 11p15 LOM = loss of methylation on chromosome 11p15; SD = standard deviation; BF+0 = Bayes factor that quantifies evidence for the one-sided alternative hypothesis that group Control is greater than group 11p15 LOM, relative to the null hypothesis; BF-0 = Bayes factor that quantifies evidence for the one-sided alternative hypothesis that group Control is smaller than group 11p15 LOM, relative to the null hypothesis. Results are based on a data augmentation algorithm with 5 chains of 1000 iterations, with 1 seed for repeatability.
a For all measures of the d2-R test, N = 15 for the 11p15LOM group.
b For all index and subscales of the BRIEF/BRIEF-A questionnaire, N = 17 for the control group.