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. 2023 Jan 20;9(3):eadd5799. doi: 10.1126/sciadv.add5799

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Fig. 2. — (A) Schematic diagram of the macroscale whole-heart FRET and optical mapping system. (B) Representative images of a cardiac-specific CAMPER mouse heart showing CFP and YFP fluorescence. Scale bar, 1 mm. (C) Temporal CFP and YFP fluorescence responses in control and CAMPER mouse hearts after application of a 1.5 μM bolus NE with corresponding changes in HR. (D) Pseudo-colored CFP/YFP ratio image (scale bar, 1mm) and (E) CFP/YFP [normalized to baseline (R₀)] ratio changes in response to 1.5 μM NE. (F) Example map of APD (APD₈₀) during sinus rhythm. (G) Example optical APs from the heart in (D) from the time points marked on the FRET ratio graph in (E) and the APD₈₀ graph in (H). (H) Temporal APD₈₀ changes in response to 1.5 μM NE.