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. 2023 Jan 11;12:e79488. doi: 10.7554/eLife.79488

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© 2023, Lafferty et al

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Figure 4. — (A) MiRNAs with significant associations, emiRs, separated by unique to blood, unique to brain, or shared. Three of 11 shared emiRs have co-localized genetic signals in the blood and brain datasets. Cartoon locus dot-plot shows a representation of a colocalized genetic signal or a non-colocalized signal for a miRNA-eQTL that is present in both tissues. (B) The fraction of brain eQTL associations that are estimated non-null associations within the blood eQTL dataset (π₁) separated by miRNA-eQTLs and mRNA-eQTLs. Error bars represent 95% upper and lower confidence intervals after 100 bootstrap samplings.