Table 2.
Species and role of lncRNAs in granulosa cell development.
| LncRNA | Target Gene | Function | Species | Reference |
|---|---|---|---|---|
| LncRNAXLOC_110025 | MOS BMP15 WNT6 CDC25A | Promote follicle development | Hy-line Brown | [122] |
| LncRNA_138134 | PSMD6 | Affect oocyte maturation | Human (GCs) | [123] |
| LncRNA_210520.2 | SOWAHA | Inhibited the proliferation of granulosa cells | Chicken (SYF) | [124] |
| Lnc RNAGLM | ERα | Regulated by estrogen through ERα | Laying hens | [125] |
| LncRNALTR | ERβ | Involved in lipid metabolism | Chicken | [10] |
| LncRAN MTSRG.17017.1 MTSRG.6475.20 |
CACNA1C
TGFB1 |
Affect gonad development and GnRH signaling pathway | White Leghorns and Beijing You chickens | [126] |
| LncRNA XLOC_001347 XLOC_016063 XLOC_02660 XLOC_03201 XLOC_005141 |
CASP6/MMP2/SMAD2 | Involved cell growth, proliferation, and development | Broody chickens (BC) and normal ovaries (NO) | [52] |
| LncRNA RP4-545C24.1 | RAD51 WT1 | Inhibition of DNA damage repair capacity | Human | [127] |
Abbreviations: MOS (MOS proto-oncogene, serine/threonine kinase); PSMD6 (proteasome 26S subunit, non-ATPase 6); sosondowah ankyrin repeat domain family member A (SOWAHA); calcium volt aggregated subunit alphal C (CACNA1C); transforming growth factor beta1 (TGFB1); caspase 6 (CASP6); RAD51 (RAD51 recombinase); WT1 transcription factor (WT1).