Table 3.

Species and role of circRNAs in granulosa cell development.

CircRNA	miRNA	Target Gene	Function	Species	Reference
circRNA-aplacirc_13267	apla-miR-1-13	THBS1	Promotes granulosa cell apoptosis	Duck	[131]
circRNA_RANBP9	miR-136-5p	XIAP	Inhibits granulosa cell apoptosis	Human (Polycystic ovary syndrome)	[132]
circRNA_EML1	miR-449a	IGF2BP3	Promotes granulosa cell steroid hormone synthesis and estrogen and progesterone secretion, down regulate miR-449a	Hyline Brown	[133]
circRNA_0320 circRNA_0185	miR-143-3p	FSHR	Promotes GC differentiation and follicle development	Chicken (SYF)	[134]
sss-circINHA-001	miR-24-5p miR-7144-3p miR-9830-5p	INHA	Resisting GC apoptosis and follicular atresia	Chicken	[135]
circRNA_8:6369673|6402248 circRNA_8:6369673|642209 circRNA_8:6384248|6402248	miR-1625-3p miR-1552-3p miR-16-2-3p miR-18b-3p miR-200a-3p	RalGPS2	Regulate GC development	Chicken (SYF/F6/F1)	[72]
novel_circ0004730	/	ESR	Cell growth, proliferation, differentiation, and apoptosis	Chicken (SYF/F6/F1)	[136]

Abbreviations: throbospondin1 (THBS1); X-linked inhibitor of apoptosis (XIAP); RalGEF with PH domain and SH3 binding motif 2 (RalGPS2).