Figure 4.

NCP contacts—involved in the stabilisation of NCP structure through the H3-latch and breathing—that could be potentially affected by PARP1 interaction and subsequent PARylation (data from [23,163,167]). Specific PARylation sites in these regions are highlighted in a mint colour and indicated by mint arrows (a dashed line for H2B contacts and a solid line for H3 contacts). DNA is blurred, and histones H2A and H4 are highlighted in white for clarity. The dyad is highlighted in orange. Dashed whitishe-pink arrows go to positions of the fluorescent dyes that were used for the investigation into the molecular dynamics of the NCP after PARP1 binding and PARylation [163,167].