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. 2023 Jan 7;14(1):165. doi: 10.3390/genes14010165

Figure 2.

Figure 2

Three-dimensional structures of the 1129 amino acid (aa) KAT6A truncating protein. The PML interaction domain (aa 144–664) and the two RUNX1-2 domains (aa 1–144 and 312–644, respectively) are required for protein interaction and activation, which were highlighted in space-filling mode. The domain 645–660 aa of the acetyl-CoA binding site is marked with a yellow circle. The deletion of the C-terminal region may increase the availability of PML in the cytoplasm and the cellular distribution of RUNX2. The ability to recognize acetil-coA, on the other hand, stays unaltered.